Início Avaliação da ocorrência de interações medicamentosas em pacientes com problemas cardiovasculares
Número atual: 9 (2022)
Avaliação da ocorrência de interações medicamentosas em pacientes com problemas cardiovasculares
Resumo:
The high demand for medication among the population is widely recognized. Although they have healing potential, the lay use of these drugs can cause harm, such as side effects and drug interactions, also highlighting their potential risk. Given the above, the objective of this study is to analyze the frequency of drug interactions in prescriptions for patients with cardiovascular diseases. This study seeks to highlight the importance of the pharmacist's role in the multidisciplinary hospital team, as well as to analyze possible drug interventions in this group. This is a retrospective, documentary study with a quantitative approach, conducted through the analysis of 80 medical records of patients hospitalized with cardiovascular diseases between August 5 and 28, 2012, in a public hospital. The results showed a high frequency of drug interactions, especially in patients with multiple prescribed drugs. Medications commonly used in the SUS (Brazilian Unified Health System) were identified among those most involved in the interactions. These findings reinforce the relevance of the clinical pharmacist's role in preventing risks and optimizing therapy.
Keywords: Interactions; Medications; Cardiovascular Diseases.
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Farmacognosia e Produtos Naturais no Controle do Vetor da Dengue: Tendências Globais e Nacionais de Pesquisa sobre Plantas Medicinais
Resumo:
Introduction: Dengue is a prevalent disease in tropical and subtropical regions, characterized by high incidence and the risk of severe outbreaks. Controlling the mosquito Aedes aegypti, the disease vector, is essential to reduce its transmission. Natural substances with larvicidal activity have emerged as sustainable alternatives to synthetic insecticides, which pose environmental risks and resistance issues. In this context, pharmacognosy investigates bioactive compounds with larvicidal potential to develop effective and safe treatments. Objectives: This study conducted a bibliometric analysis of the scientific production on medicinal plants with larvicidal action against Aedes aegypti, the dengue vector, covering the period from 1998 to 2025. Materials and methods: Using the Scopus database and tools such as Bibliometrix, global and Brazilian trends were evaluated, identifying growth in publications, predominant research areas, and collaboration among authors. Results and dissemination: The bibliometric analysis revealed a significant increase in publications since 1998, with a marked rise in recent years. Journals such as Parasitology Research, Molecules, and Journal of Vector Borne Diseases stand out in the field, along with high-impact authors like Murugan Kadarkarai and Giovanni Benelli. Studies range from the use of essential oils to the biosynthesis of nanoparticles for vector control. Countries including India, Brazil, and China lead in publication volume, demonstrating established international collaboration. In Brazil, federal universities from the North, Northeast, and Southeast regions are prominent in this research. Conclusion: The scientific output emphasizes natural and sustainable alternatives for dengue control, supported by strong cooperation among authors, institutions, and countries.
Keywords: Dengue, Natural products, Antiviral activity, Vector control, Bibliometric analysis.
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Atuação profissional dos farmacêuticos no Brasil: perfil profissional e dinâmica de trabalho nas diferentes áreas de atuação
Resumo:
Introduction: The pharmaceutical profession in Brazil has undergone significant transformations, Expanding its area of activity beyond the industrial and commercial pharmaceutical sectors. Pharmaceutical Care has consolidated itself as an essential element for healthcare, while the growth of advanced aesthetics has highlighted the aesthetic pharmacist as a rising professional. Several areas of activity require, in addition to technical knowledge, the adoption of specific biosafety measures and good professional practices. Materials and methods: This study, through an integrative review, analyzed the profile and work dynamics of pharmacists in different sectors, including community pharmacies, hospitals, industry, clinical analysis, health surveillance and aesthetics. The research was conducted in electronic scientific databases, such as Google, the Public Library of Science and the Scientific Electronic Library Online, prioritizing publications between 2020 and 2024, and resulted in the selection of 20 studies. Results and discussion: The results highlight the diversity of fields of activity of the pharmacist and the need for continuous updating. Furthermore, they highlight the importance of health education and the adoption of good biosafety practices, especially in areas involving direct contact with patients and the handling of risky supplies. Final considerations: The study broadens the understanding of the multifaceted role of pharmacists and highlights the need for policies that strengthen their performance.
Keywords: Pharmacy, Pharmaceutical profession, Job Market, Healthcare system.
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Substâncias injetáveis para tratamentos estéticos faciais: uma revisão de literatura
Resumo:
In this current scenario of globalization that we are experiencing, we are impacted by numerous pieces of information, generating a paradigm of perfect beauty, valuing the pursuit of aesthetic procedures and the desire for "perfect beauty" imposed mainly by social media. This approach of "eternal beauty" leads to a certain unease in people and consequently non-acceptance of aging, a natural phenomenon that occurs with all living beings. This behavior results in numerous consequences, from self-esteem problems to disorders related to body image. According to research conducted by the International Society of Aesthetic Plastic Surgery, 20 million cosmetic procedures were performed in 2014, with Brazil ranked third in non-surgical procedures. The methodology used in the article consists of a comprehensive literature review, using scientific databases such as PubMed/MEDLINE, Lilacs, Scielo, and Google Scholar to search for articles in Portuguese, English, and French. 44 relevant articles were selected from 80 initially found, prioritizing those that contributed to the study's objective. The focus is to present the origin, mechanism of action, applicability, and adverse effects of the main injectable substances used in aesthetic procedures: botulinum toxin, fillers, and biostimulators.
Keywords: Fillers, Hyaluronic Acid, Poly-L-Lactic Acid , Biostimulators, , Calcium Hydroxyapatite, Polycaprolactone. Botulinum Toxin.
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Terapia gênica: Os genes em busca da cura
Resumo:
The possibility of modifying human genes has been the main objective of medicine since DNA was discovered. Gene therapy can be defined as the improvement of human genes, whether to correct an anomaly, or to modify the cell or tissue, for therapeutic purposes. Gene therapy is nothing more than a medical procedure that modifies cells, with the purpose of treating or curing the gene that causes a certain disease. There are already medicines released under the regulatory category of advanced therapies, however, many other studies are still being carried out, in search of the development of new molecules. One of the most important points of gene therapy is the development of safe, effective and efficient methods for transferring genes into human cells. With the development of these new drugs, we have a very positive outlook regarding the use of these drugs in the general population, in addition to being more effective for mass diseases, such as cancer, for example.
Keywords: gene therapy, vectors, genetic transfer.
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Aromaterapia: tratamento de doenças respiratórias
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Introduction: The use of essential oils and their medicinal properties, often associated with the practice of aromatherapy, has roots in ancient Chinese and Egyptian civilizations, establishing it as a millennia-old science. Extracted from various parts of plants, primarily from the Lauraceae and Myrtaceae families, these volatile oils exhibit various biological activities, including cytotoxicity.Review: In aromatherapy, the primary absorption pathways for essential oils are inhalation, oral, and topical. Due to their volatility, oils are particularly effective when inhaled, activating olfactory nerves and connecting to the limbic system, which regulates emotions. For the treatment of respiratory diseases, a variety of essential oils stand out, among which the most relevant are eucalyptus, frankincense, pine, peppermint, lavender, and tea tree.Discussion: Essential oils are fundamental in aromatherapy, providing benefits in enhancing immunity and treating respiratory diseases. The growing interest in less invasive alternative therapies has reignited research on the efficacy of aromatherapy, especially in contrast to the side effects of conventional medications. Although their application in pharmaceuticals declined throughout the 20th century, recent studies confirm their relevance. Aromatherapy can not only reduce self-medication but also serve as a complementary option to traditional medicine, highlighting the importance of the quality and provenance of the oils used. Conclusions:Aromatherapy is an effective alternative in treating respiratory diseases, utilizing essential oils such as eucalyptus and peppermint, which possess antiseptic and anti-inflammatory properties. In addition to alleviating symptoms, it may reduce self-medication and the inappropriate use of antibiotics. The quality of essential oils is crucial, and ongoing research is necessary to consolidate aromatherapy as a recognized practice, contributing to respiratory health and overall well-being.
Keywords: Alternative therapy, Aromatherapy, Essencial oils, Respiratory diseases.
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Boas práticas para a manipulação de fármaco citotóxico oral: recomendações para os profissionais da enfermagem, pacientes e familiares
Resumo:
This study aimed to identify good practices for handling oral cytotoxic antineoplastic drugs. This is a narrative, qualitative, exploratory and explanatory bibliographic review work. The data were collected and organized in a synthesized way through the analysis of all articles used to support this scientific work, thus generating two categories of analysis that will be exposed below: care in the use of oral cytotoxic antineoplastic drugs and good practices by the team in handling these. However, it was possible to observe that it is of fundamental importance that professionals directly involved in the handling of oral antineoplastics are prepared, theoretically based to deal with the appropriate guidelines to be offered to the patient and family, in situations of handling, administration and correct disposal of drugs. cytotoxic.
Keywords: Oral cytotoxic drug, Home chemotherapy, Oral chemotherapeutic agentes, Oncology nursing, Occupational Hazards.
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Anestesia para cesariana com placenta prévia – um relato de caso
Resumo:
In Brasil, neuraxial anesthetics are preferred for cesarean sections. This is due to several factors. Among them, we can mention the safety for the parturient and the newborn, and mainly the management of postoperative pain. Furthermore, they allow parental participation in the birth, which is a unique moment in the parents’ life. But in many cases, these anesthesias are not commonly used, for instance, in the presence of placenta previa, a pathology that impacts the action of obstetricians and anesthetics. This work reports a clinical case of a pregnant woman with total center placenta previa, submitted to spinal anesthesia at the time of cesarean section. The report shows that general anesthesia is not always necessary for patients with such comorbidity, and that subarachnoid block is safe in such a scenario.
Keywords: Rachidian anesthesia, Cesarean section., Previous placenta.
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A importância da pesquisa clínica no tratamento de Mieloma Múltiplo Recidivado/Refratário (MM-RR)
Resumo:
INTRODUCTION: There is currently a deficit in the treatment of relapsed/refractory multiple myeloma, since it is a disease that is considered incurable and requires different treatment protocols with each relapse. Through clinical studies, the medical clinic has benefited from the approval of new treatments and patients have the opportunity to undergo promising treatments under free multi-professional assistance. REVIEW: A search was carried out on ClinicalTrials for ongoing clinical studies in Brazil and scientific publications containing clinical results of drugs already approved and used commercially. DISCUSSION: There has been a need for constant updating and availability of new treatments for relapsed/refractory multiple myeloma since it is still a disease without a cure. It is known that the use of subsequent drugs with different mechanisms of action to those already in use bring a greater and longer-lasting response to the patient, and constant studies are needed to understand the profile of the disease and which are the best combinations for the desired response. FINAL REMARKS: The information obtained from the literature reviews showed that conducting clinical trials is beneficial for the patient who consents to take part in the research and for updating medical practices.
Keywords: multiple myeloma, hematologic neoplasm, clinical studies, cancer, bone marrow.
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